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Saturday, January 22, 2011

An example of open innovation in medicine

From the book Flash Foresight, by Daniel Burrus, as excerpted in Fast Company:

The key to unraveling our most intractable problems often lies in recognizing that the problem confronting us is not our real problem; the real problem lies hidden behind the distraction of what we think our problem is. Skipping your biggest problem means stepping outside the flat plane of the existing situation and gaining a clearer perspective, and this often triggers flash foresights that lead to new opportunities far bigger and more productive than you could have imagined based on the original (incorrect) problem you were trying to solve.

Take Eli Lilly, for example. A Fortune 500 company and member of the S&P 500 index, Lilly was one of the largest pharmaceutical companies in the world, yet they knew they were not invulnerable. In 1992, more than a hundred years after its founding by Civil War veteran Eli Lilly, the company that brought us insulin, penicillin, and erythromycin, had suffered the first quarterly loss in its history. By 2001 Lilly faced a ticking clock. That August a key patent would expire, ending the company's exclusive on Prozac, the drug that had been responsible for a third of its annual sales of $3 billion just the year before.

Lilly was in a panic. In 1999, knowing that the Prozac patent deadline was approaching, the company had ramped up its R&D budget by 30 percent in a quest to find the next pharmaceutical blockbuster. But its profits were tumbling anyway, and so was its stock value. A pharmaceutical company's stock price is tied to whatever exciting new drugs it has in its pipeline, and not simply to how well its existing flagship products are selling. To get new drugs into the pipeline, you've got to solve molecular problems, which is why Lilly had nearly 7,000 researchers on its payroll. As large a staff as that sounds, it wasn't enough. In August 2000, when news of the patent's impending expiration hit, Lilly's stock dropped nearly one- third in value in a single day, deleting more than $36 billion in equity. Now the August 2001 deadline loomed. They had some big molecular puzzles to solve, and solving them would mean hiring at least another one thousand PhD employees--a thousand new employees they frankly did not have the money to hire.

Lilly's problem was, to put it bluntly, no money. Or was it? Actually, the key to solving Lilly's problem was to skip it-- because that wasn't its real problem. The real issue was not hiring more PhDs, it was solving molecular problems.

So what did they do? They created an online scientific forum called InnoCentive, Inc., where they posted difficult chemical and molecular problems and offered to pay anyone who could solve them. By making the site open to any scientist with an Internet connection and posting the problems in over a dozen languages, the company created a global, virtual R&D talent pool that soon found solutions to problems that had stumped its own researchers.

One of the beauties of this strategy is that the company paid only for those solutions that worked. The amount paid depended on the difficulty of the problem. Some of the awards have been as high as $100,000, although most are in the $2,000 to $3,000 bracket. To date, engineers and scientists from Beijing to Moscow have worked at solving the company's molecular problems--without being on the company's payroll. In the following years, other companies followed Eli Lilly's lead, including Procter & Gamble, Dow Chemical, and others.

They created new drugs, and their stock rebounded. Lilly survived--and thrived. (In 2006, Fortune magazine named Lilly to its list of top 100 companies to work for, and Barron's included it in its top 500 best- managed U.S. companies.)

How did Eli Lilly solve its money problem? They didn't: instead, they skipped it. In fact, their money problem was not the problem, it was only what they thought the problem was.



Of course, Eli Lilly's problems existed in the context of a mature pharmaceutical industry. But its approach to solving them raises intriguing possibilities for cryonics organizations. The process of describing and advertising for solutions to cryonics' problems in open innovation forums could go a long way towards educating the scientific and technical communities about what cryonics attempts to accomplish, and why they should accord cryonics the respect it deserves.

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